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HMGCR Antikörper (AA 629-888)
HMGCR
Reaktivität: Human
WB, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN6141869
Produktdetails anti-HMGCR Antikörper
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Target
Alle HMGCR Antikörper anzeigen
HMGCR
(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
Bindungsspezifität
Alle Epitope für HMGCR Antikörper
AA 629-888
Reaktivität
Alle Reaktivitäten für HMGCR Antikörper
Human
Wirt
Alle Wirte für HMGCR Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für HMGCR Antikörper
Polyklonal
Konjugat
Alle Konjugate für HMGCR Antikörper
Dieser HMGCR Antikörper ist unkonjugiert
Applikation
Alle Applikationen für HMGCR Antikörper
Western Blotting (WB), Immunofluorescence (IF)
Sequenz
ARLQKLHTSI AGRNLYIRFQ SRSGDAMGMN MISKGTEKAL SKLHEYFPEM QILAVSGNYC TDKKPAAINW IEGRGKSVVC EAVIPAKVVR EVLKTTTEAM IEVNINKNLV GSAMAGSIGG YNAHAANIVT AIYIACGQDA AQNVGSSNCI TLMEASGPTN EDLYISCTMP SIEIGTVGGG TNLLPQQACL QMLGVQGACK DNPGENARQL ARIVCGTVMA GELSLMAALA AGHLVKSHMI HNRSKINLQD LQGACTKKTA
Kreuzreaktivität
Human, Maus, Ratte
Produktmerkmale
Polyclonal Antibodies
Aufreinigung
Affinity purification
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 629-888 of human HMGCR (NP_000850.1).
Isotyp
IgG
Top Product
Discover our top product HMGCR Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
WB,1:500 - 1:2000,IF,1:50 - 1:200
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20°C. Avoid freeze / thaw cycles.
Details zu HMGCR
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Target
HMGCR
(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
Andere Bezeichnung
HMGCR (HMGCR Produkte )
Synonyme
HMGR antikoerper, LDLCQ3 antikoerper, hmg-coa-r antikoerper, HMG-CoAR antikoerper, Red antikoerper, 3H3M antikoerper, BcDNA:LD15354 antikoerper, CG10367 antikoerper, Clb antikoerper, DmHMG-CoAr antikoerper, Dmel\\CG10367 antikoerper, HMGCR antikoerper, HMGCR_Dm antikoerper, HMGCoAR antikoerper, HMGCoARr antikoerper, HMGCoAr antikoerper, HmG-CoAR antikoerper, Hmg antikoerper, bro1 antikoerper, bs32f05.y1 antikoerper, clb antikoerper, hmgc antikoerper, hmgcr antikoerper, hmgrc antikoerper, l(3)01152 antikoerper, l(3)04684 antikoerper, hmgcr2 antikoerper, im:6912716 antikoerper, zgc:110746 antikoerper, 3-hydroxy-3-methylglutaryl-CoA reductase antikoerper, 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog antikoerper, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase antikoerper, HMG Coenzyme A reductase antikoerper, 3-hydroxy-3-methylglutaryl-CoA reductase b antikoerper, HMGCR antikoerper, hmgcr.L antikoerper, Hmgcr antikoerper, hmgcrb antikoerper
Hintergrund
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,HMGCR,LDLCQ3,HMGCR,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,AMPK Signaling Pathway,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,HMGCR
Molekulargewicht
92 kDa/97 kDa/99 kDa
Gen-ID
3156
UniProt
P04035
Pathways
AMPK Signaling , Negative Regulation of Hormone Secretion , Regulation of Lipid Metabolism by PPARalpha
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