HLA-DMA Antikörper (AA 27-233)

Produktnummer ABIN6141805

Produktdetails anti-HLA-DMA Antikörper

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Bindungsspezifität: AA 27-233

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-DMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VPEAPTPMWP DDLQNHTFLH TVYCQDGSPS VGLSEAYDED QLFFFDFSQN TRVPRLPEFA DWAQEQGDAP AILFDKEFCE WMIQQIGPKL DGKIPVSRGF PIAEVFTLKP LEFGKPNTLV CFVSNLFPPM LTVNWQHHSV PVEGFGPTFV SAVDGLSFQA FSYLNFTPEP SDIFSCIVTH EIDRYTAIAY WVPRNALPSD LLENVLC

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-233 of human HLA-DMA (NP_006111.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HLA-DMA

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Andere Bezeichnung: HLA-DMA (HLA-DMA Produkte)

Synonyme: RT1.Ma antikoerper, RT1.DMa antikoerper, HLA-DMA antikoerper, H-2Ma antikoerper, H2-Ma antikoerper, D6S222E antikoerper, DMA antikoerper, HLADM antikoerper, RING6 antikoerper, RT1 class II, locus DMa antikoerper, SLA-DM alpha chain antikoerper, major histocompatibility complex, class II, DM alpha antikoerper, histocompatibility 2, class II, locus DMa antikoerper, RT1-DMa antikoerper, SLA-DMA antikoerper, DLA-DMA antikoerper, H2-DMa antikoerper, HLA-DMA antikoerper

Hintergrund: HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.,HLA-DMA,D6S222E,DMA,HLADM,RING6,major histocompatibility complex,class II,DM alpha,Immunology & Inflammation,Cardiovascular,Blood,HLA-DMA

Molekulargewicht: 29 kDa

Gen-ID: 3108

UniProt: P28067

Pathways: Cancer Immune Checkpoints