GCN1L1 Antikörper (AA 2462-2671)

Produktnummer ABIN6141024

Produktdetails anti-GCN1L1 Antikörper

Target: GCN1L1 (GCN1 General Control of Amino-Acid Synthesis 1-Like 1 (Yeast) (GCN1L1))

Bindungsspezifität: AA 2462-2671

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GCN1L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LSAVLQQCLL ADVSGIDWMV RHGRSLALSV AVNVAPGRLC AGRYSSDVQE MILSSATADR IPIAVSGVRG MGFLMRHHIE TGGGQLPAKL SSLFVKCLQN PSSDIRLVAE KMIWWANKDP LPPLDPQAIK PILKALLDNT KDKNTVVRAY SDQAIVNLLK MRQGEEVFQS LSKILDVASL EVLNEVNRRS LKKLASQADS TEQVDDTILT

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2462-2671 of human GCN1L1 (NP_006827.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GCN1L1

Target: GCN1L1 (GCN1 General Control of Amino-Acid Synthesis 1-Like 1 (Yeast) (GCN1L1))

Andere Bezeichnung: GCN1L1 (GCN1L1 Produkte)

Synonyme: GCN1 antikoerper, GCN1L antikoerper, PRIC295 antikoerper, 4932409G22 antikoerper, AL022764 antikoerper, G431004K08Rik antikoerper, mKIAA0219 antikoerper, GCN1, eIF2 alpha kinase activator homolog antikoerper, GCN1 general control of amino-acid synthesis 1-like 1 (yeast) antikoerper, GCN1 eIF2 alpha kinase activator-like 1 antikoerper, GCN1 antikoerper, Gcn1l1 antikoerper

Hintergrund: Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes, during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1 on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.,GCN1,GCN1L,GCN1L1,PRIC295,Epigenetics & Nuclear Signaling,GCN1L1

Molekulargewicht: 292 kDa

Gen-ID: 10985

UniProt: Q92616