FAM208A Antikörper (AA 700-1000)

Produktnummer ABIN6140453

Produktdetails anti-FAM208A Antikörper

Target: FAM208A (Family with Sequence Similarity 208, Member A (FAM208A))

Bindungsspezifität: AA 700-1000

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM208A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DTEDMRSKTV LKRKLEDLPE NMRKLAKTSN LSENCHLYEE SPQPIGSLGH DADLRRQQQD TCNSGIADIH RLFNWLSETL ANARHSDASL TDTVNKALGL STDDAYEELR QKHEYELNST PDKKDYEQPT CAKVENAQFK GTQSLLLEVD ATSKYSVAIS TSEVGTDHKL HLKEDPNLIS VNNFEDCSLC PSVPIEHGFR RQQSKSNNVE ETEIHWKLIP ITGGNARSPE DQLGKHGEKQ TPGMKSPEEQ LVCVPPQEAF PNDPRVINRQ RSSDYQFPSS PFTDTLKGTT EDDVLTGQVE E

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human FAM208A (NP_001106207.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FAM208A

Target: FAM208A (Family with Sequence Similarity 208, Member A (FAM208A))

Andere Bezeichnung: FAM208A (FAM208A Produkte)

Synonyme: c3orf63-a antikoerper, c3orf63.1 antikoerper, fam208a antikoerper, rap140 antikoerper, se89-1 antikoerper, C3orf63 antikoerper, RAP140 antikoerper, family with sequence similarity 208 member A L homeolog antikoerper, family with sequence similarity 208 member A antikoerper, fam208a.L antikoerper, FAM208A antikoerper

Hintergrund: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Plays a crucial role in early embryonic development (By similarity. Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity. Plays an important role in maintaining epiblast fitness or potency (By similarity.,FAM208A,C3orf63,RAP140,TASOR,se89-1,Epigenetics & Nuclear Signaling,RNA Binding,FAM208A

Molekulargewicht: 139 kDa/170 kDa/182 kDa/189 kDa

Gen-ID: 23272

UniProt: Q9UK61