Casein Kinase 1 gamma 2 Antikörper (AA 316-415)

Produktnummer ABIN6139122

Produktdetails anti-Casein Kinase 1 gamma 2 Antikörper

Target: Casein Kinase 1 gamma 2 (CSNK1G2) (Casein Kinase 1, gamma 2 (CSNK1G2))

Bindungsspezifität: AA 316-415

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Casein Kinase 1 gamma 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: FDRSGFVFDY EYDWAGKPLP TPIGTVHTDL PSQPQLRDKT QPHSKNQALN STNGELNADD PTAGHSNAPI TAPAEVEVAD ETKCCCFFKR RKRKSLQRHK

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 316-415 of human CSNK1G2 (NP_001310.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Casein Kinase 1 gamma 2

Target: Casein Kinase 1 gamma 2 (CSNK1G2) (Casein Kinase 1, gamma 2 (CSNK1G2))

Andere Bezeichnung: CSNK1G2 (CSNK1G2 Produkte)

Synonyme: CK1g2 antikoerper, 2810429I12Rik antikoerper, AI463719 antikoerper, CKI antikoerper, ck1-gamma antikoerper, CSNK1G2 antikoerper, ck1g2 antikoerper, csnk1g2 antikoerper, fj97g11 antikoerper, wu:fj97g11 antikoerper, wz8345 antikoerper, zgc:110719 antikoerper, zgc:153415 antikoerper, casein kinase 1 gamma 2 antikoerper, casein kinase 1, gamma 2 antikoerper, casein kinase 1 gamma 2 L homeolog antikoerper, casein kinase 1, gamma 2a antikoerper, casein kinase 1, gamma 2b antikoerper, CSNK1G2 antikoerper, Csnk1g2 antikoerper, csnk1g2.L antikoerper, csnk1g2 antikoerper, csnk1g2a antikoerper, csnk1g2b antikoerper

Hintergrund: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.,CSNK1G2,CK1g2,Cancer,Signal Transduction,Kinase,Endocrine & Metabolism,Lipid Metabolism,Stem Cells,CSNK1G2

Molekulargewicht: 47 kDa

Gen-ID: 1455

UniProt: P78368

Pathways: Hedgehog Signalweg