Aconitase 1 Antikörper
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- Target Alle Aconitase 1 (ACO1) Antikörper anzeigen
- Aconitase 1 (ACO1)
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Aconitase 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Kreuzreaktivität
- Maus, Ratte
- Produktmerkmale
- Polyclonal Antibodies
- Aufreinigung
- Affinity purification
- Immunogen
- A synthetic peptide of human IREB1
- Isotyp
- IgG
- Top Product
- Discover our top product ACO1 Primärantikörper
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- Applikationshinweise
- WB,1:500 - 1:1000
- Kommentare
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HIGH QUALITY
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Aconitase 1 (ACO1)
- Andere Bezeichnung
- ACO1 (ACO1 Produkte)
- Synonyme
- ACONS antikoerper, IREB1 antikoerper, IREBP antikoerper, IREBP1 antikoerper, IRP1 antikoerper, Acon1 antikoerper, Ratireb antikoerper, ratireb antikoerper, Aco1 antikoerper, AI256519 antikoerper, Aco-1 antikoerper, Irebp antikoerper, Irp1 antikoerper, aconitase 1 antikoerper, aconitase 1, soluble antikoerper, aconitase 1 L homeolog antikoerper, ACO1 antikoerper, Aco1 antikoerper, aco1.L antikoerper
- Hintergrund
- The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants,ACO1,ACONS,HEL60,IREB1,IREBP,IREBP1,IRP1,Epigenetics & Nuclear Signaling,Signal Transduction,Endocrine & Metabolism,Nucleotide metabolism,Cardiovascular,Blood,ACO1
- Molekulargewicht
- 98 kDa
- Gen-ID
- 48
- UniProt
- P21399
- Pathways
- Transition Metal Ion Homeostasis
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