PCSK2 Antikörper (AA 351-400)

Produktnummer ABIN6746608

Produktdetails anti-PCSK2 Antikörper

Target: PCSK2 (Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2))

Bindungsspezifität: AA 351-400

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Affe, Fledermaus, Huhn, Schwein, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCSK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Human PCSK2

Homologie: Percent identity by BLAST analysis: Human, Mouse, Dog, Bovine, Rabbit, Horse, Guinea pig, Chicken, Xenopus, Zebrafish (100%) Pig (92%).

Aufreinigung: Immunoaffinity purified

Immunogen: Synthetic peptide located between aa351-400 of human PCSK2 (Q5REC2, NP_002585). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Elephant, Dog, Bovine, Bat, Rabbit, Horse, Pig, Opossum, Guinea pig, Turkey, Chicken, Platypus, Lizard, Xenopus, Frog, Salmon, Stickleback, Medaka, Zebrafish (100%).

Type of Immunogen: Synthetic peptide

Anwendungsinformationen

Applikationshinweise: Approved: WB (0.2 - 1 μg/mL)

Usage: Western Blot: Suggested dilution at 1 μg/mL in 5 % skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Distilled water

Konzentration: Lot specific

Buffer: Lyophilized from PBS with 2 % sucrose

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year)
Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.

Referenzen für anti-PCSK2 Antikörper (ABIN6746608)

Discher, Bishopric, Wu, Peterson, Webster: "Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element." in: The Journal of biological chemistry, Vol. 273, Issue 40, pp. 26087-93, (1998) (PubMed).

Feo, Antona, Barbieri, Passantino, Calì, Giallongo: "Transcription of the human beta enolase gene (ENO-3) is regulated by an intronic muscle-specific enhancer that binds myocyte-specific enhancer factor 2 proteins and ubiquitous G-rich-box binding factors." in: Molecular and cellular biology, Vol. 15, Issue 11, pp. 5991-6002, (1995) (PubMed).

Giallongo, Venturella, Oliva, Barbieri, Rubino, Feo: "Structural features of the human gene for muscle-specific enolase. Differential splicing in the 5'-untranslated sequence generates two forms of mRNA." in: European journal of biochemistry / FEBS, Vol. 214, Issue 2, pp. 367-74, (1993) (PubMed).

Details zu PCSK2

Target: PCSK2 (Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2))

Andere Bezeichnung: PCSK2 (PCSK2 Produkte)

Synonyme: NEC 2 antikoerper, NEC-2 antikoerper, NEC2 antikoerper, PC2 antikoerper, SPC2 antikoerper, PCSK2 antikoerper, 6330411F23Rik antikoerper, AI839700 antikoerper, Nec-2 antikoerper, Nec2 antikoerper, Phpp-2 antikoerper, pc2 antikoerper, nec2 antikoerper, spc2 antikoerper, pcsk2 antikoerper, pcsk2-A antikoerper, proprotein convertase subtilisin/kexin type 2 antikoerper, proprotein convertase subtilisin/kexin type 2 L homeolog antikoerper, PCSK2 antikoerper, pcsk2 antikoerper, Pcsk2 antikoerper, pcsk2.L antikoerper

Hintergrund: Name/Gene ID: PCSK2
Subfamily: Serine S8
Family: Protease

Synonyms: PCSK2, Proprotein convertase 2, SPC2, NEC 2, NEC-2, Neuroendocrine convertase 2, PC2, KEX2-like endoprotease 2, NEC2, Prohormone convertase 2

Gen-ID: 5126

NCBI Accession: NP_002585

UniProt: P16519

Pathways: Peptide Hormone Metabolism, cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity