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EFCAB4B Antikörper

EFCAB4B Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5967195
  • Target Alle EFCAB4B Antikörper anzeigen
    EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))
    Reaktivität
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 22
    • 2
    Kaninchen
    Klonalität
    • 24
    Polyklonal
    Konjugat
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser EFCAB4B Antikörper ist unkonjugiert
    Applikation
    • 24
    • 13
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein of human CRACR2A (NP_001138430.1).
    Isotyp
    IgG
    Top Product
    Discover our top product EFCAB4B Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000 IHC 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))
    Andere Bezeichnung
    CRACR2A (EFCAB4B Produkte)
    Synonyme
    CRACR2A antikoerper, Gm1073 antikoerper, Gm462 antikoerper, calcium release activated channel regulator 2A antikoerper, CRACR2A antikoerper, Cracr2a antikoerper
    Hintergrund
    Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
    Molekulargewicht

    Observed_MW: Refer to figures

    Calculated_MW: 45kDa/83kDa

    Gen-ID
    84766
    UniProt
    Q9BSW2
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