NCOA2 Antikörper

Produktnummer ABIN5965002

Produktdetails anti-NCOA2 Antikörper

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCOA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: This antibody ist KO validated.

Aufreinigung: Affinity purification

Güteklasse: KO Validated

Immunogen: Recombinant fusion protein of human NCOA2 (NP_006531.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NCOA2

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Andere Bezeichnung: NCOA2 (NCOA2 Produkte)

Synonyme: GRIP1 antikoerper, KAT13C antikoerper, NCoA-2 antikoerper, SRC2 antikoerper, TIF2 antikoerper, bHLHe75 antikoerper, 9530095N19 antikoerper, D1Ertd433e antikoerper, GRIP-1 antikoerper, Grip1 antikoerper, SRC-2 antikoerper, TIF-2 antikoerper, tif2 antikoerper, wu:fc41a10 antikoerper, wu:fe26a11 antikoerper, Tif2 antikoerper, NCOA2 antikoerper, XTIF2 antikoerper, bhlhe75 antikoerper, grip1 antikoerper, kat13c antikoerper, src2 antikoerper, ncoa2-A antikoerper, nuclear receptor coactivator 2 antikoerper, nuclear receptor coactivator 2 S homeolog antikoerper, NCOA2 antikoerper, Ncoa2 antikoerper, ncoa2 antikoerper, LOC100089041 antikoerper, ncoa2.S antikoerper

Hintergrund: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.

Molekulargewicht:

Observed_MW: 180kDa

Calculated_MW: 159kDa

Gen-ID: 10499

UniProt: Q15596

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling