Desmocollin 1 Antikörper

Produktnummer ABIN5963313

Produktdetails anti-Desmocollin 1 Antikörper

Target: Desmocollin 1 (DSC1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Desmocollin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human DSC1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Desmocollin 1

Target: Desmocollin 1 (DSC1)

Andere Bezeichnung: DSC1 (DSC1 Produkte)

Synonyme: DSC1 antikoerper, CDHF1 antikoerper, DG2/DG3 antikoerper, DSC1b antikoerper, DG2DG3 antikoerper, dg3 antikoerper, Dsc1a antikoerper, Dsc1b antikoerper, desmocollin 1 antikoerper, DSC1 antikoerper, Dsc1 antikoerper

Hintergrund:

Synonyms: Cadherin family member 1,CDHF1,Desmocollin1,Desmosomal glycoprotein 2/3,DG2/DG3,DSC 1,DSC1

Background: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.

Molekulargewicht:

Observed_MW: 105kDa

Calculated_MW: 93kDa/99kDa

Gen-ID: 1823

UniProt: Q08554