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SLC25A22 Antikörper (Solute Carrier Family 25 (Mitochondrial Carrier: Glutamate), Member 22) (C-Term) Primary Antibody

SLC25A22 Reaktivität: Human IHC, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN572183
$454.67
Zzgl. Versandkosten $45.00
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 7 bis 8 Werktagen
  • Target
    SLC25A22
    Bindungsspezifität
    C-Term
    • 1
    • 1
    • 1
    Reaktivität
    Human
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Wirt
    Kaninchen
    • 7
    Klonalität
    Polyklonal
    • 7
    Applikation
    Immunohistochemistry (IHC), Western Blotting (WB)
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    Spezifität
    Specific for SLC25A22.
    Aufreinigung
    Whole serum
    Immunogen
    A synthetic peptide from c-terminal region of human Mitochondrial glutamate carrier 1 (SLC25A22) conjugated to an immunogenic carrier protein was used as the antigen.
  • Applikationshinweise
    A dilution of 1: 200 to 1: 2000 is recommended.
    The optimal dilution should be determined by the end user.
    Not yet tested in other applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
    Handhabung
    Avoid freeze and thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Haltbarkeit
    12 months
  • Target
    SLC25A22
    Andere Bezeichnung
    SLC25A22 (SLC25A22 Antibody Abstract)
    Synonyme
    1300006L01Rik, AI060884, Gc1, GC1, RGD1307826, EIEE3, NET44, solute carrier family 25 (mitochondrial carrier, glutamate), member 22, solute carrier family 25 member 22, Slc25a22, SLC25A22
    Hintergrund
    Function: Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H+. Defects in SLC25A22 are the cause of epileptic encephalopathy early infantile type 3 (EIEE3), also known as early myoclonic encephalopathy (EME) or neonatal epilepsy with suppression-burst pattern. Severe neonatal epilepsies with suppression-burst pattern are early-onset epileptic syndromes characterized by a typical EEG pattern. The suppression-burst pattern of the EEG is characterized by higher-voltage bursts of slow waves mixed with multifocal spikes alternating with isoelectric suppression phases. EME is characterized by a very early onset, erratic and fragmentary myoclonus, massive myoclonus, partial motor seizures and late tonic spasms. The prognosis of EME is poor, with no effective treatment, and children with the condition either die within 1 to 2 years after birth or survive in a persistent vegetative state. EME inheritance is autosomal recessive.
    Subcellular location: Mitochondrion inner membrane, Multi-pass membrane protein
    Tissue specificity: Highly expressed in most tissues. Also known as: GC-1, Glutamate/H(+) symporter 1, Solute carrier family 25 member 22, SLC25A22, GC1.
    Pathways
    Dicarboxylic Acid Transport
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