TRPC4 Antikörper

Produktnummer ABIN571659

Produktdetails anti-TRPC4 Antikörper

Target: TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRPC4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Spezifität: Specific for TRPC4. See also the immunogen.

Immunogen: A synthetic peptide from human TRPC4 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many other species.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu TRPC4

Target: TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))

Andere Bezeichnung: TRPC4 (TRPC4 Produkte)

Synonyme: TRPC5 antikoerper, TRPC4 antikoerper, HTRP-4 antikoerper, HTRP4 antikoerper, TRP4 antikoerper, CCE1 antikoerper, STRPC4 antikoerper, Trp4 antikoerper, Trrp4 antikoerper, transient receptor potential cation channel subfamily C member 4 antikoerper, short transient receptor potential channel 4 antikoerper, transient receptor potential cation channel, subfamily C, member 4 antikoerper, TRPC4 antikoerper, LOC100538928 antikoerper, trpc4 antikoerper, Trpc4 antikoerper

Hintergrund: Function: Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Subunit: Isoform alpha but not isoform beta associates with inositol-1,4,5-triphosphate receptor (ITPR). Interacts with NHERF.
Subcellular location: Membrane, Multi-pass membrane protein. -
Tissue specificity: Abundantly expressed in brain (hippocampal CA1 pyramidal neurons, dentate gyrus granule cells, and cerebral cortical neurons, and in the septal nuclei and the mitral layer ofolfactory bulb). Lower levels are detected in other tissues. -
Tissue specificity: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. Also known as: Short transient receptor potential channel 4, TrpC4, Trp4, Capacitative calcium entry channel 1, CCE1, Trrp4, Receptor-activated cation channel TRP4, Trp-related protein 4, hTrp-4, hTrp4.