SMARCA4 Antikörper

Produktnummer ABIN5708236

Produktdetails anti-SMARCA4 Antikörper

Target: SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMARCA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity purified

Immunogen: A recombinant human protein corresponding to amino acids Q555-E763 was used as the immunogen for the BRG1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the BRG1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL, IHC (FFPE): 1-2 μg/mL, Direct ELISA: 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the BRG1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu SMARCA4

Target: SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4))

Andere Bezeichnung: BRG1 / SMARCA4 (SMARCA4 Produkte)

Synonyme: SMARCA4 antikoerper, BAF190 antikoerper, BAF190A antikoerper, BRG1 antikoerper, MRD16 antikoerper, RTPS2 antikoerper, SNF2 antikoerper, SNF2L4 antikoerper, SNF2LB antikoerper, SWI2 antikoerper, hSNF2b antikoerper, brg-1 antikoerper, Brg1 antikoerper, HP1-BP72 antikoerper, SNF2beta antikoerper, SW1/SNF antikoerper, b2b692Clo antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 antikoerper, SMARCA4 antikoerper, Smarca4 antikoerper

Hintergrund: Transcription activator BRG1 also known as ATP-dependent helicase SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene. The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: P51532

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance