RRP8 Antikörper

Produktnummer ABIN5705951

Produktdetails anti-RRP8 Antikörper

Target: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRP8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogen: ribosomal RNA processing 8, methyltransferase, homolog (yeast)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

human brain tissue were subjected to SDS PAGE followed by western blot with FNab07501(RRP8 antibody) at dilution of 1:1500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu RRP8

Target: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Andere Bezeichnung: RRP8 (RRP8 Produkte)

Synonyme: KIAA0409 antikoerper, 1500003O22Rik antikoerper, 2900001K19Rik antikoerper, AW538116 antikoerper, RGD1308302 antikoerper, ribosomal RNA processing 8 antikoerper, ribosomal RNA processing 8, methyltransferase, homolog (yeast) antikoerper, RRP8 antikoerper, Rrp8 antikoerper

Hintergrund: Synonyms:KIAA0409, NML Background:Essential component of the eNoSC(energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9'(H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Gen-ID: 23378

UniProt: O43159