CHFR Antikörper

Produktnummer ABIN5705429

Produktdetails anti-CHFR Antikörper

Target: CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHFR Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Immunogen: checkpoint with forkhead and ring finger domains

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab01648(CHFR antibody) at dilution of 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu CHFR

Target: CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))

Andere Bezeichnung: CHFR (CHFR Produkte)

Synonyme: RNF116 antikoerper, RNF196 antikoerper, CHFR antikoerper, fc43f10 antikoerper, si:dkey-69h6.7 antikoerper, wu:fc43f10 antikoerper, rnf116 antikoerper, rnf196 antikoerper, 5730484M20Rik antikoerper, C230082M18 antikoerper, checkpoint with forkhead and ring finger domains antikoerper, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase antikoerper, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog antikoerper, CHFR antikoerper, chfr antikoerper, Chfr antikoerper, chfr.L antikoerper

Hintergrund: Synonyms:RNF196 Background:E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2(UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Molekulargewicht: 70-85 kDa

Gen-ID: 55743

UniProt: Q96EP1