PRR5 Antikörper

Produktnummer ABIN5705367

Produktdetails anti-PRR5 Antikörper

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Immunogen: proline rich 5 (renal)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

human kidney tissue were subjected to SDS PAGE followed by western blot with FNab06830(PRR5 antibody) at dilution of 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu PRR5

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Andere Bezeichnung: PRR5 (PRR5 Produkte)

Synonyme: AU043908 antikoerper, Arhgap8 antikoerper, C030017C09Rik antikoerper, C78947 antikoerper, Protor-1 antikoerper, Protor1 antikoerper, FLJ20185k antikoerper, PP610 antikoerper, PROTOR-1 antikoerper, PROTOR1 antikoerper, pp610 antikoerper, protor1 antikoerper, protor2 antikoerper, proline rich 5 (renal) antikoerper, proline rich 5 antikoerper, proline rich 5 L homeolog antikoerper, Prr5 antikoerper, PRR5 antikoerper, prr5.L antikoerper

Hintergrund: Synonyms:PROTOR1 Background:Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.

Gen-ID: 55615

UniProt: P85299

Pathways: PI3K-Akt Signalweg