NMRAL1 Antikörper

Produktnummer ABIN5704605

Produktdetails anti-NMRAL1 Antikörper

Target: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMRAL1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Immunogen: NmrA-like family domain containing 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab05769(NMRAL1 antibody) at dilution of 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu NMRAL1

Target: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Andere Bezeichnung: NMRAL1 (NMRAL1 Produkte)

Synonyme: HSCARG antikoerper, SDR48A1 antikoerper, 1110025F24Rik antikoerper, AI256624 antikoerper, RGD1311451 antikoerper, NmrA like redox sensor 1 antikoerper, NmrA-like family domain containing 1 antikoerper, NMRAL1 antikoerper, Nmral1 antikoerper

Hintergrund: Synonyms:HSCARG Background:Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase(ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.

Molekulargewicht: 33 kDa

Gen-ID: 57407

UniProt: Q9HBL8