VPS41 Antikörper

Produktnummer ABIN5704546

Produktdetails anti-VPS41 Antikörper

Target: VPS41 (Vacuolar Protein Sorting 41 Homolog (VPS41))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS41 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Immunogen: vacuolar protein sorting 41 homolog (S. cerevisiae)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB :1:200-1:1000,IF:1:10-1:100

Kommentare:

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09442(VPS41 antibody) at dilution of 1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu VPS41

Target: VPS41 (Vacuolar Protein Sorting 41 Homolog (VPS41))

Andere Bezeichnung: VPS41 (VPS41 Produkte)

Synonyme: AI317346 antikoerper, Vam2 antikoerper, mVam2 antikoerper, HVPS41 antikoerper, HVSP41 antikoerper, hVps41p antikoerper, RGD1560511 antikoerper, ATVAM2 antikoerper, ATVPS41 antikoerper, T23G18.5 antikoerper, T23G18_5 antikoerper, VACUOLAR PROTEIN SORTING 41 antikoerper, VAM2 antikoerper, ZIGZAG SUPPRESSOR 2 antikoerper, ZIP2 antikoerper, vacuolar protein sorting 41 antikoerper, Vacuolar assembly protein VPS41 homolog antikoerper, VPS41, HOPS complex subunit antikoerper, vacuolar protein sorting 41 antikoerper, vacuolar protein sorting 41, putative antikoerper, Vacuolar protein sorting-associated protein 41 homolog antikoerper, VPS41 HOPS complex subunit antikoerper, Bm1_34430 antikoerper, VPS41 antikoerper, CNI02550 antikoerper, CC1G_08871 antikoerper, MCYG_00680 antikoerper, VDBG_03430 antikoerper, MGYG_01292 antikoerper, CGB_H3560C antikoerper, vps-41 antikoerper, Vps41 antikoerper

Hintergrund: Synonyms:HVPS41, hVps41p, HVSP41, S53, VPS41 Background:Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes(PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo(PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes(PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion(PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS(PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex(By similarity). May play a role in HOPS-independent function in the regulated secretory pathway(PubMed:24210660).

Molekulargewicht: 102kDa

Gen-ID: 27072

UniProt: P49754