R-Spondin 3 Antikörper

Produktnummer ABIN5704254

Produktdetails anti-R-Spondin 3 Antikörper

Target: R-Spondin 3 (RSPO3)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser R-Spondin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: R-spondin 3 homolog (Xenopus laevis)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab07512( RSPO3 Antibody) at dilution of 1:300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu R-Spondin 3

Target: R-Spondin 3 (RSPO3)

Andere Bezeichnung: RSPO3 (RSPO3 Produkte)

Synonyme: pwtsr antikoerper, thsd2 antikoerper, cristin1 antikoerper, CRISTIN1 antikoerper, PWTSR antikoerper, THSD2 antikoerper, RGD1563246 antikoerper, 2810459H04Rik antikoerper, AW742308 antikoerper, Cristin1 antikoerper, Thsd2 antikoerper, R-spondin 3 antikoerper, rspo3 antikoerper, RSPO3 antikoerper, Rspo3 antikoerper

Hintergrund: Synonyms:CRISTIN1, hPWTSR, hRspo3, Protein with TSP type 1 repeat, PWTSR, R spondin 3, Roof plate specific spondin 3, RSPO3, THSD2 Background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6(LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway(PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells(By similarity).

Gen-ID: 84870

UniProt: Q9BXY4