HMHA1 Antikörper

Produktnummer ABIN5702949

Produktdetails anti-HMHA1 Antikörper

Target: HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMHA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: histocompatibility (minor) HA-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03935(HMHA1 antibody) at dilution of 1:800

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu HMHA1

Target: HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))

Andere Bezeichnung: HMHA1 (HMHA1 Produkte)

Synonyme: RGD1308662 antikoerper, MGC80108 antikoerper, hmha1 antikoerper, arhgap45 antikoerper, ha-1 antikoerper, HMHA1 antikoerper, DKFZp469A2018 antikoerper, ARHGAP45 antikoerper, HA-1 antikoerper, HLA-HA1 antikoerper, 6330406L22Rik antikoerper, AW539505 antikoerper, Ha-1 antikoerper, Rho GTPase activating protein 45 antikoerper, Rho GTPase activating protein 45 L homeolog antikoerper, histocompatibility (minor) HA-1 b antikoerper, Arhgap45 antikoerper, ARHGAP45 antikoerper, arhgap45.L antikoerper, hmha1b antikoerper, arhgap45 antikoerper

Hintergrund: Synonyms:KIAA0223 Background:GTPase activator for the Rho-type GTPases. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens(mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease(GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation(BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte(CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.

Molekulargewicht: 140-150 kDa

Gen-ID: 23526

UniProt: Q92619