FBXO6 Antikörper

Produktnummer ABIN5702804

Produktdetails anti-FBXO6 Antikörper

Target: FBXO6 (F-Box Protein 6 (FBXO6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXO6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: F-box protein 6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab03048(FBXO6 antibody) at dilution of 1:300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu FBXO6

Target: FBXO6 (F-Box Protein 6 (FBXO6))

Andere Bezeichnung: FBXO6 (FBXO6 Produkte)

Synonyme: FBG2 antikoerper, FBS2 antikoerper, FBX6 antikoerper, Fbx6b antikoerper, AA408845 antikoerper, Fbs2 antikoerper, Fbxo6b antikoerper, Fbg2 antikoerper, FBXO6 antikoerper, fbg2 antikoerper, fbs2 antikoerper, fbx6 antikoerper, fbx6b antikoerper, fbxo44 antikoerper, F-box protein 6 antikoerper, F-box protein 6 S homeolog antikoerper, FBXO6 antikoerper, Fbxo6 antikoerper, fbxo6.S antikoerper

Hintergrund: Synonyms:FBG2, FBS2, FBX6 Background:Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway(ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1(phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Molekulargewicht: 35 kDa

Gen-ID: 26270

UniProt: Q9NRD1