BHLHE22 Antikörper

Produktnummer ABIN5702193

Produktdetails anti-BHLHE22 Antikörper

Target: BHLHE22 (Basic Helix-Loop-Helix Family, Member E22 (BHLHE22))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BHLHE22 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Immunogen: basic helix-loop-helix family, member e22

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu BHLHE22

Target: BHLHE22 (Basic Helix-Loop-Helix Family, Member E22 (BHLHE22))

Andere Bezeichnung: BHLHE22 (BHLHE22 Produkte)

Synonyme: bhlhb5 antikoerper, MGC145865 antikoerper, BHLHE22 antikoerper, Beta3.1 antikoerper, wu:fq25e11 antikoerper, zgc:64225 antikoerper, BHLHB5 antikoerper, Beta3 antikoerper, CAGL85 antikoerper, TNRC20 antikoerper, Bhlhb5 antikoerper, basic helix-loop-helix family member e22 antikoerper, basic helix-loop-helix family, member e22 antikoerper, bhlhe22 antikoerper, BHLHE22 antikoerper, Bhlhe22 antikoerper

Hintergrund: Synonyms:BHLHB5, TNRC20 Background:Inhibits DNA binding of TCF3/E47 homodimers and TCF3(E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA(By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.

Molekulargewicht: 37 kDa

Gen-ID: 27319

UniProt: Q8NFJ8