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AKAP8L Antikörper

AKAP8L Reaktivität: Human WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5702022
  • Target Alle AKAP8L Antikörper anzeigen
    AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))
    Reaktivität
    • 39
    • 13
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 39
    Kaninchen
    Klonalität
    • 39
    Polyklonal
    Konjugat
    • 22
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AKAP8L Antikörper ist unkonjugiert
    Applikation
    • 29
    • 18
    • 8
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Immunogen
    A kinase (PRKA) anchor protein 8-like
    Isotyp
    IgG
    Top Product
    Discover our top product AKAP8L Primärantikörper
  • Applikationshinweise
    WB :1:200-1:2000,IF:1:20-200
    Kommentare

    PC-3 cells were subjected to SDS PAGE followed by western blot with FNab00258( AKAP8L Antibody) at dilution of 1:300

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze / thaw cycles.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))
    Andere Bezeichnung
    AKAP8L (AKAP8L Produkte)
    Synonyme
    HA95 antikoerper, HAP95 antikoerper, NAKAP antikoerper, NAKAP95 antikoerper, Nakap95 antikoerper, zgc:85966 antikoerper, AKAP8L antikoerper, A-kinase anchoring protein 8 like antikoerper, A kinase (PRKA) anchor protein 8-like antikoerper, A-kinase anchoring protein 8 like L homeolog antikoerper, AKAP8L antikoerper, Akap8l antikoerper, akap8l antikoerper, akap8l.L antikoerper
    Hintergrund
    Synonyms:A kinase anchor protein 8 like, AKAP8 like protein, AKAP8L, DKFZp434L0650, HA95, HAP95, Helicase A binding protein 95, Homologous to AKAP95 protein, NAKAP, NAKAP95, Neighbor of AKAP95 Background:Could play a role in constitutive transport element(CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export(PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA(PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis(PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta(PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3, in this function seems to act redundantly with AKAP8(PubMed:16980585). May be involved in regulation of pre-mRNA splicing(PubMed:17594903). (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters(PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses(PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription, in vitro negatively regulates DHX9 annealing activity(PubMed:25034436).
    Molekulargewicht
    72kDa
    Gen-ID
    26993
    UniProt
    Q9ULX6
    Pathways
    SARS-CoV-2 Protein Interaktom
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