CRBN Antikörper

Produktnummer ABIN5701681

Produktdetails anti-CRBN Antikörper

Target: CRBN (Cereblon (CRBN))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRBN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Immunogen: cereblon

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab01954(CRBN antibody) at dilution of 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu CRBN

Target: CRBN (Cereblon (CRBN))

Andere Bezeichnung: CRBN (CRBN Produkte)

Synonyme: zgc:92404 antikoerper, mrt2a antikoerper, F3N11.21 antikoerper, MRT2 antikoerper, MRT2A antikoerper, 2610203G15Rik antikoerper, 2900045O07Rik antikoerper, AF229032 antikoerper, AW108261 antikoerper, piL antikoerper, cereblon antikoerper, ATP-dependent protease La (LON) domain protein antikoerper, crbn antikoerper, CRBN antikoerper, AT2G25740 antikoerper, Crbn antikoerper

Hintergrund: Synonyms:cereblon, CRBN, MRT2A, Protein cereblon Background:Substrate recognition component of a DCX(DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.

Molekulargewicht: 53 kDa

Gen-ID: 51185

UniProt: Q96SW2