HTRA1 Antikörper

Produktnummer ABIN5699275

Produktdetails anti-HTRA1 Antikörper

Target: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HTRA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Immunogen: HtrA serine peptidase 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

L02 cells were subjected to SDS PAGE followed by western blot with FNab04069(HTRA1 antibody) at dilution of 1:600

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu HTRA1

Target: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Andere Bezeichnung: HTRA1 (HTRA1 Produkte)

Synonyme: htra1 antikoerper, zgc:92029 antikoerper, zgc:172061 antikoerper, l56 antikoerper, htra antikoerper, Xhtra1 antikoerper, prss11 antikoerper, MGC145723 antikoerper, ARMD7 antikoerper, CARASIL antikoerper, HtrA antikoerper, L56 antikoerper, ORF480 antikoerper, PRSS11 antikoerper, AI429470 antikoerper, HTRA antikoerper, Prss11 antikoerper, RSPP11 antikoerper, HTRA1 antikoerper, HtrA serine peptidase 1a antikoerper, HtrA serine peptidase 1 antikoerper, HtrA serine peptidase 1b antikoerper, Serine protease HTRA1 antikoerper, HtrA serine peptidase 1 S homeolog antikoerper, htra1a antikoerper, HTRA1 antikoerper, htra1b antikoerper, htra1 antikoerper, Htra1 antikoerper, htra1.S antikoerper

Hintergrund: Synonyms:HTRA, PRSS11 Background:Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors(IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Molekulargewicht: 35 kDa, 50 kD, 42 kDa

Gen-ID: 5654

UniProt: Q92743

Pathways: Growth Factor Binding