DNA Helicase B Antikörper

Produktnummer ABIN5699254

Produktdetails anti-DNA Helicase B Antikörper

Target: DNA Helicase B (HELB)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNA Helicase B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Immunogen: helicase (DNA) B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu DNA Helicase B

Target: DNA Helicase B (HELB)

Andere Bezeichnung: HELB (HELB Produkte)

Synonyme: RGD1560103 antikoerper, hDHB antikoerper, AI447783 antikoerper, D10Ertd664e antikoerper, DNA helicase B antikoerper, helicase (DNA) B antikoerper, Helb antikoerper, HELB antikoerper

Hintergrund: Synonyms: Background:5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection(PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA(ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB(PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation(PubMed:26774285). Acts independently of TP53BP1(PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates(PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress(PubMed:22194613).

Molekulargewicht: 120-140 kDa

Gen-ID: 92797

UniProt: Q8NG08