SPAG5 Antikörper

Produktnummer ABIN5698126

Produktdetails anti-SPAG5 Antikörper

Target: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPAG5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Immunogen: sperm associated antigen 5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab08143(SPAG5 antibody) at dilution of 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu SPAG5

Target: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Andere Bezeichnung: SPAG5 (SPAG5 Produkte)

Synonyme: SPAG5 antikoerper, DEEPEST antikoerper, MAP126 antikoerper, hMAP126 antikoerper, AI874642 antikoerper, D11Bhm180e antikoerper, Deepest antikoerper, Mastrin antikoerper, S17 antikoerper, sperm associated antigen 5 antikoerper, sperm-associated antigen 5 antikoerper, SPAG5 antikoerper, LOC739263 antikoerper, Spag5 antikoerper

Hintergrund: Synonyms: Background:Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase(PubMed:11724960, PubMed:12356910). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture(PubMed:17664331). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes(PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2(PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1(mTORC1) association and recruits the mTORC1 component RPTOR to stress granules(SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis(PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU(PubMed:18055457).

Gen-ID: 10615

UniProt: Q96R06

Pathways: M Phase