CLASP2 Antikörper

Produktnummer ABIN5697482

Produktdetails anti-CLASP2 Antikörper

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLASP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Immunogen: cytoplasmic linker associated protein 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu CLASP2

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Andere Bezeichnung: CLASP2 (CLASP2 Produkte)

Synonyme: zgc:77279 antikoerper, DKFZp459M112 antikoerper, 1500004F14Rik antikoerper, 8030404L10Rik antikoerper, C77448 antikoerper, CLASP2beta antikoerper, mKIAA0627 antikoerper, cytoplasmic linker associated protein 2 antikoerper, CLIP associating protein 2 antikoerper, clasp2 antikoerper, CLASP2 antikoerper, Clasp2 antikoerper

Hintergrund: Synonyms:KIAA0627 Background:Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules(PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network(TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2(PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle(PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Molekulargewicht: 140-160 kDa

Gen-ID: 23122

UniProt: O75122

Pathways: Microtubule Dynamics, Maintenance of Protein Location