BBS7 Antikörper

Produktnummer ABIN5697175

Produktdetails anti-BBS7 Antikörper

Target: BBS7 (Bardet-Biedl Syndrome 7 (BBS7))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BBS7 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Immunogen: Bardet-Biedl syndrome 7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu BBS7

Target: BBS7 (Bardet-Biedl Syndrome 7 (BBS7))

Andere Bezeichnung: BBS7 (BBS7 Produkte)

Synonyme: BBS7 antikoerper, bbs2l1 antikoerper, BBS2L1 antikoerper, id:ibd5048 antikoerper, zgc:153772 antikoerper, 8430406N16Rik antikoerper, Bardet-Biedl syndrome 7 antikoerper, bardet-biedl syndrome 7 antikoerper, Bardet-Biedl syndrome 7 L homeolog antikoerper, Bardet-Biedl syndrome 7 (human) antikoerper, BBS7 antikoerper, bbs7 antikoerper, MICPUN_100192 antikoerper, MICPUCDRAFT_16331 antikoerper, bbs7.L antikoerper, Bbs7 antikoerper

Hintergrund: Synonyms:BBS2L1 Background:The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Gen-ID: 55212

UniProt: Q8IWZ6

Pathways: Hedgehog Signalweg