CHM Antikörper (AA 193-380)

Produktnummer ABIN5693178

Produktdetails anti-CHM Antikörper

Target: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Bindungsspezifität: AA 193-380

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for CHM detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.

Immunogen: E. coli-derived human CHM recombinant protein (Position: A193-Q380).

Anwendungsinformationen

Applikationshinweise:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Application Details: Western blot, 0.1-0.5 μg/mL
Direct ELISA, 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Details zu CHM

Target: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Andere Bezeichnung: CHM (CHM Produkte)

Synonyme: CHM antikoerper, REP1 antikoerper, DXS540 antikoerper, GGTA antikoerper, HSD-32 antikoerper, REP-1 antikoerper, TCD antikoerper, DKFZp459K2154 antikoerper, tcd antikoerper, ggta antikoerper, rep-1 antikoerper, dxs540 antikoerper, hsd-32 antikoerper, MGC68578 antikoerper, Rep-1 antikoerper, chm antikoerper, chm-a antikoerper, chm-b antikoerper, chml antikoerper, CHM, Rab escort protein 1 antikoerper, choroideremia (Rab escort protein 1) antikoerper, choroideremia (Rab escort protein 1) L homeolog antikoerper, choroidermia (RAB escort protein 1) antikoerper, choroideremia (Rab escort protein 1) S homeolog antikoerper, CHM antikoerper, chm antikoerper, chm.L antikoerper, Chm antikoerper, chm.S antikoerper

Hintergrund:

Synonyms: Rab proteins geranylgeranyltransferase component A 1, Choroideremia protein, Rab escort protein 1, REP-1, TCD protein, CHM, REP1, TCD

Background: Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene. This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia, also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.

UniProt: P24386

Pathways: Sensory Perception of Sound