NPC1 Antikörper (AA 1022-1278)
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- Target Alle NPC1 Antikörper anzeigen
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
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Bindungsspezifität
- AA 1022-1278
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NPC1 Antikörper ist unkonjugiert
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Applikation
- ELISA, Western Blotting (WB)
- Kreuzreaktivität (Details)
- No cross reactivity with other proteins.
- Produktmerkmale
- Rabbit IgG polyclonal antibody for Niemann Pick C1 detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.
- Immunogen
- E. coli-derived human Niemann Pick C1 recombinant protein (Position: A1022-F1278).
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- Discover our top product NPC1 Primärantikörper
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- Applikationshinweise
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Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.
Application Details: Western blot,0.1-0.5 μg/mL
Direct ELISA,0.1-0.5 μg/mL - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
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- Target
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
- Andere Bezeichnung
- NPC1 (NPC1 Produkte)
- Synonyme
- NPC antikoerper, 9130221N23Rik antikoerper, Gm243 antikoerper, Cdig2 antikoerper, im:7149020 antikoerper, wu:fb53a12 antikoerper, wu:fc29a12 antikoerper, A430089E03Rik antikoerper, C85354 antikoerper, D18Ertd139e antikoerper, D18Ertd723e antikoerper, lcsd antikoerper, nmf164 antikoerper, spm antikoerper, NPC intracellular cholesterol transporter 1 antikoerper, NPC1 like intracellular cholesterol transporter 1 antikoerper, Niemann-Pick disease, type C1 antikoerper, Niemann-Pick C1 protein antikoerper, NPC1 antikoerper, Npc1l1 antikoerper, Npc1 antikoerper, npc1 antikoerper, LOC579887 antikoerper
- Hintergrund
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Synonyms: Niemann-Pick C1 protein, NPC1
Background: Niemann-Pick disease, type C1 (NPC1) is a membrane protein that mediates intracellular cholesterol trafficking in mammals. In humans it is encoded by the NPC1 gene (chromosome location 18q11). This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
- UniProt
- O15118
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