TAS2R140 Antikörper (AA 100-150)

Produktnummer ABIN5690299

Produktdetails anti-TAS2R140 Antikörper

Target: TAS2R140 (Taste Receptor, Type 2, Member 140 (TAS2R140))

Bindungsspezifität: AA 100-150

Reaktivität: Ratte, Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAS2R140 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Spezifität: TRB3 antibody is human, mouse and rat reactive. At least two isoforms of TRB3 are known to exist, this antibody will detect both isoforms.

Aufreinigung: TRB3 antibody is affinity chromatography purified via peptide column.

Immunogen: TRB3 antibody was raised against a 17 amino acid peptide near the center of human TRB3.

The immunogen is located within amino acids 100 - 150 of TRB3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TRB3 antibody can be used for detection of TRB3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TRB3 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: TRB3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu TAS2R140

Target: TAS2R140 (Taste Receptor, Type 2, Member 140 (TAS2R140))

Andere Bezeichnung: TRB3 (TAS2R140 Produkte)

Synonyme: T2R40 antikoerper, T2r34 antikoerper, TRB3 antikoerper, TRB5 antikoerper, Tas2r13 antikoerper, Tas2r137 antikoerper, Tas2r40 antikoerper, Tas2r8 antikoerper, mTRB3 antikoerper, mt2r64 antikoerper, taste receptor, type 2, member 140 antikoerper, Tas2r140 antikoerper

Hintergrund: TRB3 was initially identified as a novel kinase-like gene that was overexpressed in multiple human tumors and regulated by hypoxia (1). In the liver, TRB3 binds and inhibits AKT activity, leading to impaired insulin signaling (2), whereas in adipose tissue TRB3 is involved in the regulation of fatty acid oxidation through ubiquitination of Acetyl-CoA carboxylase (3). Endoplasmic reticulum (ER) stress induces TRB3 expression in skeletal muscle, leading to a decrease in insulin signaling and glucose uptake, suggesting that inhibition of TRB3 expression may be a potential therapeutic treatment for managing insulin resistance (4).

Molekulargewicht: Predicted: 39 kDa

Observed: 39 kDa

Gen-ID: 57761

NCBI Accession: NP_066981

UniProt: Q96RU7