DKFZp469P1320 antikoerper, PAT2 antikoerper, TRAMD1 antikoerper, A530067G19Rik antikoerper, Tramd1 antikoerper, Pat2 antikoerper, solute carrier family 36 member 2 antikoerper, solute carrier family 36 (proton/amino acid symporter), member 2 antikoerper, SLC36A2 antikoerper, Slc36a2 antikoerper
Hintergrund
SLC36A2 is a pH -dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline (1,2). Both SLC36A2 and its paralog SLC36A1 are expressed in neurons, but SLC36A2 localizes to the endoplasmic reticulum and recycling endosome, while SLC36A1 is expressed in the lysosome (2). SLC36A2 is thought to contribute to neuronal transport and sequestration of amino acids such as glycine, alanine, and proline (2). Mutations in this gene are associated with iminoglycinuria and hyperglycinuria (3).