DIS3L2 Antikörper (AA 720-770)

Produktnummer ABIN5689946

Produktdetails anti-DIS3L2 Antikörper

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Bindungsspezifität: AA 720-770

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIS3L2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist, this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.

Aufreinigung: DIS3L2 antibody is affinity chromatography purified via peptide column.

Immunogen: DIS3L2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DIS3L2.

The immunogen is located within amino acids 720 - 770 of DIS3L2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: DIS3L2 antibody can be used for detection of DIS3L2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: DIS3L2 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: DIS3L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu DIS3L2

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Andere Bezeichnung: DIS3L2 (DIS3L2 Produkte)

Synonyme: RGD1560168 antikoerper, DIS3L2 antikoerper, DKFZp469O0522 antikoerper, FAM6A antikoerper, PRLMNS antikoerper, hDIS3L2 antikoerper, 4930429A22Rik antikoerper, 8030493P09Rik antikoerper, DIS3-like 3'-5' exoribonuclease 2 antikoerper, DIS3 like 3'-5' exoribonuclease 2 antikoerper, DIS3-like exonuclease 2 antikoerper, Dis3l2 antikoerper, DIS3L2 antikoerper, LOC100344728 antikoerper

Hintergrund: The exosome is involved in a multitude of cellular RNA processing and degradation events (1). DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2). DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3). DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4). DIS3L2 mutations have also been associated with sporadic Wilms tumors (3).

Molekulargewicht: Predicted: 97 kDa

Observed: 94 kDa

Gen-ID: 129563

NCBI Accession: NP_689596

UniProt: Q8IYB7

Pathways: Stem Cell Maintenance