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AIMP2 Antikörper (AA 150-200)
AIMP2
Reaktivität: Human
WB, ELISA, IHC (p), IF
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN5688957
Produktdetails anti-AIMP2 Antikörper
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Target
Alle AIMP2 Antikörper anzeigen
AIMP2
(Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))
Bindungsspezifität
Alle Epitope für AIMP2 Antikörper
AA 150-200
Reaktivität
Alle Reaktivitäten für AIMP2 Antikörper
Human
Wirt
Alle Wirte für AIMP2 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für AIMP2 Antikörper
Polyklonal
Konjugat
Alle Konjugate für AIMP2 Antikörper
Dieser AIMP2 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für AIMP2 Antikörper
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
Spezifität
AIMP2 antibody is human specific. AIMP2 antibody is predicted to not cross-react with AIMP1.
Aufreinigung
AIMP2 antibody is affinity chromatography purified via peptide column.
Immunogen
AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2. The immunogen is located within amino acids 150 - 200 of AIMP2.
Isotyp
IgG
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Alternativen
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Anwendungsinformationen
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Applikationshinweise
AIMP2 antibody can be used for detection of AIMP2 by Western blot at 1 - 2 μ,g/mL.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
AIMP2 antibody is supplied in PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
AIMP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Details zu AIMP2
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Target
AIMP2
(Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))
Andere Bezeichnung
AIMP2 (AIMP2 Produkte )
Synonyme
jtv1 antikoerper, MGC53242 antikoerper, pro0992 antikoerper, JTV1 antikoerper, JTV-1 antikoerper, P38 antikoerper, AA407136 antikoerper, AA407225 antikoerper, Aimp2(p38) antikoerper, Jtv1 antikoerper, aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 L homeolog antikoerper, aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 antikoerper, aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antikoerper, aimp2.L antikoerper, aimp2 antikoerper, AIMP2 antikoerper, Aimp2 antikoerper
Hintergrund
AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson's disease, accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4).
Molekulargewicht
Predicted: 35 kDa Observed: 36 kDa
Gen-ID
7965
NCBI Accession
NP_006294
UniProt
Q13155
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