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Caspase 12 Antikörper (N-Term)

CASP12 Reaktivität: Human, Maus, Ratte WB, IF, IP Wirt: Ratte Monoclonal 14F4 unconjugated
Produktnummer ABIN567796
  • Target Alle Caspase 12 (CASP12) Antikörper anzeigen
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    Bindungsspezifität
    • 16
    • 15
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 95-318, N-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 89
    • 3
    • 1
    Ratte
    Klonalität
    • 90
    • 3
    Monoklonal
    Konjugat
    • 40
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Caspase 12 Antikörper ist unkonjugiert
    Applikation
    • 79
    • 40
    • 29
    • 28
    • 26
    • 26
    • 21
    • 19
    • 10
    • 6
    • 5
    • 5
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    Spezifität
    This antibody reacts with Caspase-12 (~53 kDa) on Western blotting, Immunoprecipitation and Immunocytochemistry.
    Aufreinigung
    Protein-G Agarose Chromatography of hybridoma supernatant.
    Immunogen
    Recombinant Caspase-12 N-terminal fragment (aa 95-318).
    Klon
    14F4
    Isotyp
    IgG2a
    Top Product
    Discover our top product CASP12 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.2 containing 50 % Glycerol without preservatives.
    Konservierungsmittel
    Without preservative
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C.
  • Target
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    Andere Bezeichnung
    Caspase-12 (CASP12 Produkte)
    Synonyme
    Caspase-12 antikoerper, CASP-12 antikoerper, CASP12P1 antikoerper, caspase 12 antikoerper, caspase 12 (gene/pseudogene) antikoerper, Casp12 antikoerper, CASP12 antikoerper
    Hintergrund
    Caspase-12 is localized to the endoplasmic reticulum (ER), but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis and accumulation of excess proteins in ER, but not by membrane- or mitochondrial-targeted apoptotic signals. One well-known cause of ER stress in neurons is the accretion of amyloid-beta, the insoluble protein that forms plaques in the brains of patients with Alzheimer's disease. Caspase-12 mediates cytotoxicity induced by amyloid-beta and ER stress-induced apoptosis. Caspase-12 is ubiquitously expressed in tissues. Similar to other members of the Caspase family, Caspase-12 requires cleavage of the prodomain to activate its proapoptotic form.Synonyms: CASP-12, CASP12, Inactive caspase-12
    Gen-ID
    100506742
    NCBI Accession
    NP_001177945
    UniProt
    Q6UXS9
    Pathways
    Apoptose, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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