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Rekombinanter RSV (Felvizumab Biosimilar) Antikörper

Reaktivität: Respiratory Syncytial Virus (RSV) ELISA, Func Wirt: Human Monoclonal RSHZ19 unconjugated Recombinant Antibody
Produktnummer ABIN5668206
  • Target Alle RSV (Felvizumab Biosimilar) Produkte
    RSV (Felvizumab Biosimilar)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    Respiratory Syncytial Virus (RSV)
    Wirt
    • 1
    • 1
    Human
    Klonalität
    • 2
    Monoklonal
    Konjugat
    • 2
    Dieser RSV (Felvizumab Biosimilar) Antikörper ist unkonjugiert
    Applikation
    ELISA, Functional Studies (Func)
    Spezifität
    This antibody is specific for the conserved fusion (F) protein of RSV.
    Produktmerkmale

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Aufreinigung
    Purified antibody.
    Reinheit
    > 98 % as determined by SDS-PAGE
    Endotoxin-Niveau
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
    Klon
    RSHZ19
    Isotyp
    IgG1 kappa
  • Applikationshinweise
    Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    RSV (Felvizumab Biosimilar)
    Abstract
    RSV (Felvizumab Biosimilar) Produkte
    Substanzklasse
    Biosimilar
    Hintergrund
    SB 209763, respiratory syncytial virus
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