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ADAM17 Antikörper (C-Term)

ADAM17 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5663782
  • Target Alle ADAM17 Antikörper anzeigen
    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
    Bindungsspezifität
    • 16
    • 13
    • 13
    • 8
    • 8
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 115
    • 54
    • 52
    • 4
    • 4
    • 4
    • 1
    • 1
    Human
    Wirt
    • 100
    • 13
    • 2
    • 1
    • 1
    Kaninchen
    Klonalität
    • 92
    • 25
    Polyklonal
    Konjugat
    • 54
    • 11
    • 8
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ADAM17 Antikörper ist unkonjugiert
    Applikation
    • 87
    • 53
    • 40
    • 15
    • 14
    • 14
    • 12
    • 11
    • 10
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Sequenz
    KQYESLSLFH PSNVEMLSSM DSASVRIIKP FPAPQTPGRL QPAPVIPSAP AAPKLDHQRM DTIQEDPSTD SHMDEDGFEK DPFPNSSTAA KSFEDLTDHP VTRSEKAASF KLQRQNRVDS KETEC
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    A synthetic peptide corresponding to a sequence within amino acids 700 to the C-terminus of human ADAM17 (NP_003174.3).
    Isotyp
    IgG
    Top Product
    Discover our top product ADAM17 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IHC,1:100 - 1:200,IF,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
    Andere Bezeichnung
    ADAM17 (ADAM17 Produkte)
    Synonyme
    ADAM18 antikoerper, CD156B antikoerper, CSVP antikoerper, NISBD antikoerper, TACE antikoerper, CD156b antikoerper, Tace antikoerper, adam17 antikoerper, si:dkey-81b15.2 antikoerper, adam18 antikoerper, cd156b antikoerper, csvp antikoerper, tace antikoerper, fc20b01 antikoerper, wu:fc20b01 antikoerper, zgc:63886 antikoerper, ADAM metallopeptidase domain 17 antikoerper, a disintegrin and metallopeptidase domain 17 antikoerper, ADAM metallopeptidase domain 17b antikoerper, ADAM metallopeptidase domain 17 L homeolog antikoerper, ADAM metallopeptidase domain 17a antikoerper, ADAM17 antikoerper, Adam17 antikoerper, adam17b antikoerper, adam17.L antikoerper, adam17a antikoerper
    Hintergrund
    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.,ADAM17,ADAM18,CD156B,CSVP,NISBD,NISBD1,TACE,Cancer,Invasion and Metastasis,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Extracellular Matrix,ADAM Protein Family,Ubiquitin,Notch Signaling Pathway,Endocrine & Metabolism,Immunology & Inflammation,CD markers,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Stem Cells,ADAM17
    Molekulargewicht
    78 kDa/93 kDa
    Gen-ID
    6868
    UniProt
    P78536
    Pathways
    Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus
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