R-Spondin 3 Antikörper (AA 214-248)

Produktnummer ABIN5647910

Produktdetails anti-R-Spondin 3 Antikörper

Target: R-Spondin 3 (RSPO3)

Bindungsspezifität: AA 214-248

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser R-Spondin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 214-248 from the human protein was used as the immunogen for the RSPO3 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western blot: 1:1000-2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the RSPO3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu R-Spondin 3

Target: R-Spondin 3 (RSPO3)

Andere Bezeichnung: RSPO3 / R-spondin 3 (RSPO3 Produkte)

Synonyme: pwtsr antikoerper, thsd2 antikoerper, cristin1 antikoerper, CRISTIN1 antikoerper, PWTSR antikoerper, THSD2 antikoerper, RGD1563246 antikoerper, 2810459H04Rik antikoerper, AW742308 antikoerper, Cristin1 antikoerper, Thsd2 antikoerper, R-spondin 3 antikoerper, rspo3 antikoerper, RSPO3 antikoerper, Rspo3 antikoerper

Hintergrund: R-spondin-3 is an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Gen-ID: 84870

UniProt: Q9BXY4