NFKB1 Antikörper

Produktnummer ABIN3032043

Produktdetails anti-NFKB1 Antikörper

Target: NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NFKB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Aufreinigung: Purified

Immunogen: This NFKB1 antibody was produced from a mouse immunized with a recombinant protein from human NFKB1.

Klon: 1298CT792-105-117-133

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Titration of the NFKB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Flow Cytometry: 1:25,IHC (Paraffin): 1:25,Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the NFKB1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu NFKB1

Target: NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))

Andere Bezeichnung: NFKB1 (NFKB1 Produkte)

Synonyme: GKLP antikoerper, NKTL antikoerper, NTKL antikoerper, P105 antikoerper, TAPK antikoerper, TEIF antikoerper, TRAP antikoerper, EBP-1 antikoerper, KBF1 antikoerper, NF-kB1 antikoerper, NF-kappa-B antikoerper, NF-kappaB antikoerper, NFKB-p105 antikoerper, NFKB-p50 antikoerper, NFkappaB antikoerper, p105 antikoerper, p50 antikoerper, NF-kB antikoerper, NF-KB1 antikoerper, ebp-1 antikoerper, kbf1 antikoerper, nf-kappa-b antikoerper, nf-kappaB antikoerper, nfkb-p105 antikoerper, nfkb-p50 antikoerper, NF-kappaB1 antikoerper, p50/p105 antikoerper, BICDR-1 antikoerper, bicdr1 antikoerper, ccdc64 antikoerper, SCY1 like pseudokinase 1 antikoerper, nuclear factor kappa B subunit 1 antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog antikoerper, nuclear factor NF-kappa-B p105 subunit antikoerper, nucleoporin 107 antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 antikoerper, SCYL1 antikoerper, NFKB1 antikoerper, Nfkb1 antikoerper, nfkb1.L antikoerper, CpipJ_CPIJ012236 antikoerper, Nup107 antikoerper, nfkb1 antikoerper

Hintergrund: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NFkB is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NFkB complexes are held in the cytoplasm in an inactive state complexed with members of the NFkB inhibitor (I-kappa-B) family. In a conventional activation pathway, IkB is phosphorylated by IkB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NFkB complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NFkB p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NFkB proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling, active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

UniProt: P19838

Pathways: p53 Signalweg, NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteine