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CHD5 Antikörper (AA 64-98)

CHD5 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5647082
  • Target Alle CHD5 Antikörper anzeigen
    CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
    Bindungsspezifität
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 64-98
    Reaktivität
    • 20
    • 3
    • 1
    Human
    Wirt
    • 18
    • 1
    • 1
    Kaninchen
    Klonalität
    • 19
    • 1
    Polyklonal
    Konjugat
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CHD5 Antikörper ist unkonjugiert
    Applikation
    • 7
    • 7
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Aufreinigung
    Antigen affinity purified
    Immunogen
    A portion of amino acids 64-98 from the human protein was used as the immunogen for the CHD5 antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product CHD5 Primärantikörper
  • Applikationshinweise
    Western blot: 1:1000-2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the CHD5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
    Andere Bezeichnung
    CHD5 / Chromodomain-helicase-DNA-binding protein 5 (CHD5 Produkte)
    Synonyme
    CHD-5 antikoerper, 4930532L22Rik antikoerper, AW060752 antikoerper, B230399N07Rik antikoerper, CHD5 antikoerper, chromodomain helicase DNA binding protein 5 antikoerper, potassium voltage-gated channel subfamily A regulatory beta subunit 2 antikoerper, CHD5 antikoerper, Chd5 antikoerper, chd5 antikoerper, KCNAB2 antikoerper
    Hintergrund
    Chromodomain-helicase-DNA-binding protein 5 is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
    Gen-ID
    26038
    UniProt
    Q8TDI0
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