STIM1 Antikörper (AA 24-685)

Produktnummer ABIN563045

Produktdetails anti-STIM1 Antikörper

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Bindungsspezifität: AA 24-685

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STIM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Verwendungszweck: Mouse monoclonal antibody raised against a full length recombinant STIM1.

Sequenz: SHSHSEKATG TSSGANSEES TAAEFCRIDK PLCHSEDEKL SFEAVRNIHK LMDDDANGDV DVEESDEFLR EDLNYHDPTV KHSTFHGEDK LISVEDLWKA WKSSEVYNWT VDEVVQWLIT YVELPQYEET FRKLQLSGHA MPRLAVTNTT MTGAVLKMTD RSHRQKLQLK ALDTVLFGPP LLTRHNHLKD FMLVVSIVIG VGGCWFAYIQ NRYSKEHMKK MMKDLEGLHR AEQSLHDLQE RLHKAQEEHR TVEVEKVHLE KKLRDEINLA KQEAQRLKEL REGTENERSR QKYAEEELEQ VREALRKAEK ELESHSSWYA PEALQKWLQL THEVEVQYYN IKKQNAEKQL LVAKEGAEKI KKKRNTLFGT FHVAHSSSLD DVDHKILTAK QALSEVTAAL RERLHRWQQI EILCGFQIVN NPGIHSLVAA LNIDPSWMGS TRPNPAHFIM TDDVDDMDEE IVSPLSMQSP SLQSSVRQRL TEPQHGLGSQ RDLTHSDSES SLHMSDRQRV APKPPQMSRA ADEALNAMTS NGSHRLIEGV HPGSLVEKLP DSPALAKKAL LALNHGLDKA HSLMELSPSA PPGGSPHLDS SRSHSPSSPD PDTPSPVGDS RALQASRNTR IPHLAGKKAV AEEDNGSIGE ETDSSPGRKK FPLKIFKKPL KK

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: STIM1 (AAH21300, 24 a.a. ~ 685 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Klon: 5A2

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-STIM1 Antikörper (ABIN563045)

Hong, Chang, Wang, Yu, Lee: "IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: A plausible mechanism of IL-9R in atopic dermatitis." in: Journal of dermatological science, Vol. 78, Issue 3, pp. 206-14, (2015) (PubMed).

Umemura, Baljinnyam, Feske, De Lorenzo, Xie, Feng, Oda, Makino, Fujita, Yokoyama, Iwatsubo, Chen, Goydos, Ishikawa, Iwatsubo: "Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration." in: PLoS ONE, Vol. 9, Issue 2, pp. e89292, (2014) (PubMed).

Ferdaus, Xiao, Ohara, Nemoto, Harada, Saar, Hübner, Isomura, Nabika: "Identification of Stim1 as a candidate gene for exaggerated sympathetic response to stress in the stroke-prone spontaneously hypertensive rat." in: PLoS ONE, Vol. 9, Issue 4, pp. e95091, (2014) (PubMed).

Jans, Mottram, Johnson, Brown, Sikkink, Ross, Reynolds: "Lysophosphatidic acid promotes cell migration through STIM1- and Orai1-mediated Ca2+(i) mobilization and NFAT2 activation." in: The Journal of investigative dermatology, Vol. 133, Issue 3, pp. 793-802, (2013) (PubMed).

Eylenstein, Schmidt, Gu, Yang, Schmid, Schmidt, Alesutan, Szteyn, Regel, Shumilina, Lang: "Transcription factor NF-?B regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions." in: The Journal of biological chemistry, Vol. 287, Issue 4, pp. 2719-30, (2012) (PubMed).

Elvers, Herrmann, Seizer, Münzer, Beck, Schönberger, Borst, Martin-Romero, Lang, May, Gawaz: "Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation." in: Blood, Vol. 120, Issue 6, pp. 1317-26, (2012) (PubMed).

Henke, Albrecht, Pfeiffer, Toutzaris, Zanger, Methner: "Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress." in: The Journal of biological chemistry, Vol. 287, Issue 50, pp. 42042-52, (2012) (PubMed).

Schmid, Bhandaru, Nurbaeva, Yang, Szteyn, Russo, Leibrock, Tyan, Pearce, Shumilina, Lang: "SGK3 regulates Ca(2+) entry and migration of dendritic cells." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 30, Issue 6, pp. 1423-35, (2012) (PubMed).

Kiviluoto, Decuypere, De Smedt, Missiaen, Parys, Bultynck: "STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function." in: Skeletal muscle, Vol. 1, Issue 1, pp. 16, (2011) (PubMed).

Steinbeck, Henke, Opatz, Gruszczynska-Biegala, Schneider, Theiss, Hamacher, Steinfarz, Golz, Brüstle, Kuznicki, Methner: "Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy." in: Experimental neurology, Vol. 232, Issue 2, pp. 185-94, (2011) (PubMed).

Schuhmann, Stegner, Berna-Erro, Bittner, Braun, Kleinschnitz, Stoll, Wiendl, Meuth, Nieswandt: "Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 3, pp. 1536-42, (2010) (PubMed).

Saitoh, Oritani, Saito, Yokota, Ichii, Sudo, Fujita, Nakajima, Okada, Kanakura: "Identification of functional domains and novel binding partners of STIM proteins." in: Journal of cellular biochemistry, Vol. 112, Issue 1, pp. 147-56, (2010) (PubMed).

Braun, Gessner, Varga-Szabo, Syed, Konrad, Stegner, Vögtle, Schmidt, Nieswandt: "STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation." in: Blood, Vol. 113, Issue 5, pp. 1097-104, (2009) (PubMed).

Wu, Wang, Young, Lai, Li: "Proteome-wide identification of novel binding partners to the oncogenic fusion gene protein, NPM-ALK, using tandem affinity purification and mass spectrometry." in: The American journal of pathology, Vol. 174, Issue 2, pp. 361-70, (2009) (PubMed).

Beyersdorf, Braun, Vögtle, Varga-Szabo, Galdos, Kissler, Kerkau, Nieswandt: "STIM1-independent T cell development and effector function in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 6, pp. 3390-7, (2009) (PubMed).

Pani, Ong, Brazer, Liu, Rauser, Singh, Ambudkar: "Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 47, pp. 20087-92, (2009) (PubMed).

Alicia, Angélica, Carlos, Alfonso, Vaca: "STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: moving TRPC1 in and out of lipid rafts." in: Cell calcium, Vol. 44, Issue 5, pp. 479-91, (2008) (PubMed).

Pani, Ong, Liu, Rauser, Ambudkar, Singh: "Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE)." in: The Journal of biological chemistry, Vol. 283, Issue 25, pp. 17333-40, (2008) (PubMed).

Varga-Szabo, Braun, Kleinschnitz, Bender, Pleines, Pham, Renné, Stoll, Nieswandt: "The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction." in: The Journal of experimental medicine, Vol. 205, Issue 7, pp. 1583-91, (2008) (PubMed).

Grosse, Braun, Varga-Szabo, Beyersdorf, Schneider, Zeitlmann, Hanke, Schropp, Mühlstedt, Zorn, Huber, Schmittwolf, Jagla, Yu, Kerkau, Schulze, Nehls, Nieswandt: "An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice." in: The Journal of clinical investigation, Vol. 117, Issue 11, pp. 3540-50, (2007) (PubMed).

Details zu STIM1

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Andere Bezeichnung: STIM1 (STIM1 Produkte)

Synonyme: stim1 antikoerper, MGC76045 antikoerper, STIM1 antikoerper, si:dkey-24p1.5 antikoerper, MGC154748 antikoerper, si:ch211-112l17.2 antikoerper, Stim1 antikoerper, D11S4896E antikoerper, GOK antikoerper, TAM antikoerper, SIM antikoerper, stromal interaction molecule 1 antikoerper, stromal interaction molecule 1a antikoerper, stromal interaction molecule 1 L homeolog antikoerper, stromal interaction molecule 1b antikoerper, STIM1 antikoerper, stim1 antikoerper, stim1a antikoerper, stim1.L antikoerper, stim1b antikoerper, Stim1 antikoerper

Hintergrund: Full Gene Name: stromal interaction molecule 1
Synonyms: D11S4896E,GOK

Gen-ID: 6786

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling