CARD10 Antikörper (N-Term)

Produktnummer ABIN1449965

Produktdetails anti-CARD10 Antikörper

Target: CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD10 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid synthetic peptide near the amino terminus of human CARMA3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CARD10

Target: CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Andere Bezeichnung: CARD10 / CARMA3 (CARD10 Produkte)

Synonyme: CARD10 antikoerper, BIMP1 antikoerper, CARMA3 antikoerper, AI449026 antikoerper, Bimp1 antikoerper, Carma3 antikoerper, caspase recruitment domain family, member 10 antikoerper, caspase recruitment domain family member 10 antikoerper, Card10 antikoerper, CARD10 antikoerper

Hintergrund: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein binds to BCL10 and activates NF-kB Recent experiments have shown that CARMA3 is required for EGF-induced NF-kB activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.Synonyms: BIMP1, CARD10, Caspase recruitment domain family member 10

Gen-ID: 29775

NCBI Accession: NP_055365

Pathways: S100 Proteine