UNG Antikörper (C-Term)

Produktnummer ABIN501106

Produktdetails anti-UNG Antikörper

Target: UNG (Uracil-DNA Glycosylase (UNG))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects Uracil-DNA glycosylase (UNG) at C-term. The antibody will not cross-react with UNG2.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography

Immunogen: UNG1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human UNG1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Abstract: UNG Produkte

Synonyme: DGU antikoerper, HIGM4 antikoerper, HIGM5 antikoerper, UDG antikoerper, UNG1 antikoerper, UNG15 antikoerper, UNG2 antikoerper, ung antikoerper, zgc:56102 antikoerper, PSPTO4236 antikoerper, BA5648 antikoerper, ECK2578 antikoerper, JW2564 antikoerper, An02g14790 antikoerper, AO090001000732 antikoerper, DDBDRAFT_0204444 antikoerper, DDBDRAFT_0214910 antikoerper, DDB_0204444 antikoerper, DDB_0214910 antikoerper, uracil-DNA glycosylase antikoerper, uracil DNA glycosylase antikoerper, uracil DNA glycosylase a antikoerper, uracil-DNA glycosylase Ung antikoerper, uracil-DNA-glycosylase antikoerper, uracil DNA glycosylase L homeolog antikoerper, uracil glycosylase antikoerper, temporal expression: early antikoerper, ung antikoerper, ung2 antikoerper, Ung antikoerper, UNG antikoerper, unga antikoerper, STY2840 antikoerper, ung.L antikoerper, ANI_1_3358024 antikoerper, AOR_1_1318164 antikoerper, uglA antikoerper, Arnit_2731 antikoerper, D4R antikoerper

Substanzklasse: Viral Protein

Hintergrund: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner.Synonyms: DGU, UDG, UNG1, UNG15

Gen-ID: 7374

NCBI Accession: NP_003353

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response