FAIM3 Antikörper (C-Term)

Produktnummer ABIN501016

Produktdetails anti-FAIM3 Antikörper

Target: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAIM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects FAIM3 / TOSO.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Affinity chromatography

Immunogen: Toso antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human Toso.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu FAIM3

Target: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Andere Bezeichnung: FAIM3 / TOSO (FAIM3 Produkte)

Synonyme: FAIM3 antikoerper, FCMR antikoerper, TOSO antikoerper, 1810037B05Rik antikoerper, FcmuR antikoerper, Toso antikoerper, Fc fragment of IgM receptor antikoerper, FCMR antikoerper, Fcmr antikoerper

Hintergrund: Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex. Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS-PAGE.Synonyms: Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso

Gen-ID: 9214

NCBI Accession: NP_005440