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MACC1 Antikörper (Center)

MACC1 Reaktivität: Human, Ratte, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500214
  • Target Alle MACC1 Antikörper anzeigen
    MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))
    Bindungsspezifität
    • 15
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Center
    Reaktivität
    Human, Ratte, Maus
    Wirt
    • 27
    • 2
    Kaninchen
    Klonalität
    • 26
    • 3
    Polyklonal
    Konjugat
    • 11
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MACC1 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 13
    • 13
    • 10
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects MACC1 at center.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    MACC1 antibody was raised against a 17 amino acid peptide near the center of human MACC1.
    Isotyp
    IgG
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    Discover our top product MACC1 Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 1-2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))
    Andere Bezeichnung
    MACC1 (MACC1 Produkte)
    Synonyme
    7A5 antikoerper, SH3BP4L antikoerper, 4732474O15Rik antikoerper, Gm267 antikoerper, 7a5 antikoerper, RGD1309838 antikoerper, MACC1, MET transcriptional regulator antikoerper, metastasis associated in colon cancer 1 antikoerper, MACC1 antikoerper, Macc1 antikoerper
    Hintergrund
    Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.Synonyms: Metastasis-associated in colon cancer protein 1
    Gen-ID
    346389
    UniProt
    Q6ZN28
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