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IRGM Antikörper (Center)

IRGM Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500070
  • Target Alle IRGM Antikörper anzeigen
    IRGM (Immunity-Related GTPase Family, M (IRGM))
    Bindungsspezifität
    • 15
    • 13
    • 9
    • 7
    • 6
    • 1
    • 1
    • 1
    Center
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 43
    • 4
    Kaninchen
    Klonalität
    • 43
    • 4
    Polyklonal
    Konjugat
    • 13
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IRGM Antikörper ist unkonjugiert
    Applikation
    • 46
    • 23
    • 19
    • 13
    • 13
    • 12
    • 11
    • 5
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects IRGM at center.
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    IRGM antibody was raised against a 14 amino acid peptide near the center of the human IRGM.
    Isotyp
    IgG
    Top Product
    Discover our top product IRGM Primärantikörper
  • Applikationshinweise
    ELISA: Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    IRGM (Immunity-Related GTPase Family, M (IRGM))
    Andere Bezeichnung
    IRGM / LRG-47 (IRGM Produkte)
    Synonyme
    Ifi1 antikoerper, Iigp3 antikoerper, Iipg3 antikoerper, Irgm antikoerper, LRG-47 antikoerper, IFI1 antikoerper, IRGM1 antikoerper, LRG47 antikoerper, immunity-related GTPase family M member 1 antikoerper, immunity-related GTPase M antikoerper, immunity related GTPase M antikoerper, immunity-related GTPase family M protein antikoerper, Irgm1 antikoerper, Irgm antikoerper, IRGM antikoerper, LOC481473 antikoerper
    Hintergrund
    Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.Synonyms: IFI1, IRGM1, Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LRG47
    Gen-ID
    345611
    UniProt
    F8VPC9
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