SLC39A1 Antikörper (N-Term)

Produktnummer ABIN783795

Produktdetails anti-SLC39A1 Antikörper

Target: SLC39A1 (Solute Carrier Family 39 (Zinc Transporter), Member 1 (SLC39A1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC39A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects Zinc transporter ZIP1 / SLC39A1 at N-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the amino terminus of human ZIP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu SLC39A1

Target: SLC39A1 (Solute Carrier Family 39 (Zinc Transporter), Member 1 (SLC39A1))

Andere Bezeichnung: Zinc Transporter ZIP1 / SLC39A1 (SLC39A1 Produkte)

Synonyme: cb629 antikoerper, DrZIP1 antikoerper, sb:cb629 antikoerper, zgc:111852 antikoerper, frzip1p antikoerper, zip1 antikoerper, zirtl antikoerper, ZIP1 antikoerper, ZIRTL antikoerper, Zip1 antikoerper, Zirtl antikoerper, solute carrier family 39 (zinc transporter), member 1 antikoerper, solute carrier family 39 member 1 antikoerper, solute carrier family 39 member 1 L homeolog antikoerper, slc39a1 antikoerper, Slc39a1 antikoerper, SLC39A1 antikoerper, slc39a1.L antikoerper

Hintergrund: ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappaB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.Synonyms: IRT1, Solute carrier family 39 member 1, ZIP-1, ZIP1, ZIRTL, Zinc-iron-regulated transporter-like, Zrt- and Irt-like protein 1

Gen-ID: 27173

NCBI Accession: NP_055252

UniProt: Q9NY26

Pathways: Autophagie