CACNA2D1 Antikörper (Internal Region)

Produktnummer ABIN374788

Produktdetails anti-CACNA2D1 Antikörper

Target: CACNA2D1 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser CACNA2D1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: C-QEIFNKYNKD KKVR

Spezifität: This antibody recognizes CACNA2D1.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Synthetic peptide from the internal region of Human CACNA2D1 (NP_000713.2) Genename: CACNA2D1

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/16000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CACNA2D1

Target: CACNA2D1 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1))

Andere Bezeichnung: CACNA2D1 (CACNA2D1 Produkte)

Synonyme: CACNA2D1 antikoerper, DKFZp469K2211 antikoerper, CACNA2 antikoerper, CACNL2A antikoerper, CCHL2A antikoerper, Ca(v)alpha2delta1 antikoerper, Cacna2 antikoerper, Cchl2a antikoerper, CCHLA2 antikoerper, DHSCCA antikoerper, calcium voltage-gated channel auxiliary subunit alpha2delta 1 antikoerper, calcium channel, voltage-dependent, alpha 2/delta subunit 1 antikoerper, calcium channel, voltage-dependent, alpha2/delta subunit 1 antikoerper, CACNA2D1 antikoerper, cacna2d1 antikoerper, Cacna2d1 antikoerper

Hintergrund: Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling. The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.Synonyms: CACNL2A, CCHL2A, MHS3, Voltage-dependent calcium channel subunit alpha-2/delta-1

Molekulargewicht: 123 kDa (NP_000713.2)

Gen-ID: 781, 9606

UniProt: P54289