TNKS2 Antikörper (AA 800-900)

Produktnummer ABIN401534

Produktdetails anti-TNKS2 Antikörper

Target: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Bindungsspezifität: AA 800-900

Reaktivität: Human, Maus, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser TNKS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects Tankyrase-2 (TANK2). No cross-reactivity expected with TANK1.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Canine (Dog).
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Affinity Chromatography using the immunizing peptide.

Immunogen: Fusion protein containing 73 aa from aa 800-900 region of the protein sequence according to NP_079511.1. Genename: TNKS2

Anwendungsinformationen

Applikationshinweise: Western blot: 0.5-1.5 μg/mL. In transfected HEK293 transiently expressing TANK2 a band of approx.127 kDa is observed. This band is not observed in the non-transfected HEK293. The calculated molecular size is127 kDa according to NP_079511.1. Full caption (see picture below): HEK293 overexpressing TANK2 (lane 4) and TANK1 (lane 2)and probed with ABIN401534 (mock transfection in first lane). Lane three is empty. Lowerpanel shows the same lysates probed for alpha-Actin to show protein levels. Primaryincubation (0.5 μg/mL) was overnight at 4 °C. Detected by chemiluminescence.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu TNKS2

Target: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Andere Bezeichnung: Tankyrase-2 (TANK2) (TNKS2 Produkte)

Synonyme: ARTD6 antikoerper, PARP-5b antikoerper, PARP-5c antikoerper, PARP5B antikoerper, PARP5C antikoerper, TANK2 antikoerper, TNKL antikoerper, pART6 antikoerper, 5430432P15Rik antikoerper, AA517131 antikoerper, AI662480 antikoerper, TNKS-2 antikoerper, Tank2 antikoerper, tankyrase-2 antikoerper, TNKS2 antikoerper, tankyrase-1 antikoerper, tnks antikoerper, tnks.L antikoerper, tnks2 antikoerper, tankyrase 2 antikoerper, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antikoerper, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog antikoerper, TNKS2 antikoerper, Tnks2 antikoerper, tnks2 antikoerper, tnks.S antikoerper

Hintergrund: Tankyrase 2 may regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. It has PARP activity and can modify TRF1, and thereby contribute to the regulation of telomere length. Tankyrase 2 is highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Also highly expressed in fetal liver, heart and brain. Tankyrase 2 shares approximately 83 % sequence identity with Tankyrase 1.Synonyms: PARP5B, TNKL, TNKS-2, TNKS2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein

Gen-ID: 80351

NCBI Accession: NP_079511

UniProt: Q9H2K2